Film ini bercerita tentang mantan pembunuh bayaran, John Wick (Keanu Reeves), yang kembali beraksi. Kali ini, John harus menghadapi krisis identitas yang mempertanyakan jati dirinya sebagai seorang suami yang bersedih atas kematian istrinya atau seorang pembunuh bayaran internasional tanpa belas kasihan.
- Keanu Reeves as Jonathan “John” Wick, an ex-hitman
- Common as the head of security for a female crime lord
- Laurence Fishburne as The Bowery King, a ruthless crime lord
- Riccardo Scamarcio as Santino, an assassin
- Ruby Rose as Ares, an assassin
- John Leguizamo as Aurelio, the owner of a high-end chop shop
- Ian McShane as Winston, the owner of the Continental Hotel
- Bridget Moynahan as Helen Wick, John’s deceased wife
- Lance Reddick as Charon, the concierge at the Continental Hotel
- Thomas Sadoski sebagai Jimmy, petugas kepolisian dan teman John
- David Patrick KCharlie sebagai Charlie The Cleaner
- Peter Stormare
- Franco Nero
- Peter Serafinowicz